Genesis 16:11 (NKJV)
And the Angel of the LORD said to her:
"Behold, you are with child, And you shall bear a son. You shall call his name Ishmael, Because the LORD has heard your affliction."
And they sat down to eat a meal. Then they lifted their eyes and looked, and there was a company of Ishmaelites, coming from Gilead with their camels, bearing spices, balm, and myrrh, on their way to carry them down to Egypt. So Judah said to his brothers, "What profit is there if we kill our brother and conceal his blood? Come and let us sell him to the Ishmaelites, and let not our hand be upon him, for he is our brother and our flesh." And his brothers listened. Then Midianite traders passed by; so the brothers pulled Joseph up and lifted him out of the pit, and sold him to the Ishmaelites for twenty shekels of silver. And they took Joseph to Egypt.
The name Ishmael means "God hears" or "God will hear," given because "the LORD has heard your affliction" (Genesis 16:11). This divine acknowledgment of Hagar's suffering establishes a significant theological theme.
In Genesis 37:25-29, the Ishmaelites—descendants of Ishmael—become the instruments through which Joseph is sold into slavery. This creates a profound irony:
The Ishmaelites coming from Gilead carries additional significance: